GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7762018 | 1 | rs6942332 | chr6:170131934 | WDR27 | chr6:169857307-170102159:- | -0.19 | -5.83 | 1.04E-8 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs875971 | 1 | rs6945843 | chr7:65734783 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.24 | 2.68E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6945843 | chr7:65734783 | GUSB | chr7:65425675-65447246:- | -0.29 | -5.57 | 4.23E-8 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6945843 | chr7:65734783 | RABGEF1 | chr7:66093890-66276446:+ | -0.66 | -14.35 | 4.51E-39 | Aortic root size |
| THCA | cis | rs7097 | 1 | rs694609 | chr13:28194806 | POLR1D | chr13:28194895-28241547:+ | -0.18 | -4.2 | 3.16E-5 | Large B-cell lymphoma |
| THCA | cis | rs6946131 | 1 | rs6946131 | chr7:54783373 | SEC61G | chr7:54819941-54826939:- | 0.16 | 4.66 | 4.17E-6 | Systemic lupus erythematosus |
| THCA | cis | rs875971 | 1 | rs6946143 | chr7:65579722 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.13 | 4.3E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6946143 | chr7:65579722 | GUSB | chr7:65425675-65447246:- | 0.25 | 4.71 | 3.22E-6 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6946143 | chr7:65579722 | RABGEF1 | chr7:66093890-66276446:+ | 0.65 | 13.38 | 6.7E-35 | Aortic root size |
| THCA | cis | rs6947471 | 1 | rs6947471 | chr7:154381475 | LOC100132707 | chr7:154720227-154741194:+ | 0.23 | 3.51 | 0.00049 | Pelvic organ prolapse |
| THCA | cis | rs4730250 | 1 | rs6947674 | chr7:107193504 | DLD | chr7:107531586-107561642:+ | 0.15 | 3.58 | 0.00038 | Osteoarthritis |
| THCA | cis | rs1801085 | 1 | rs6948297 | chr7:27149404 | HOXA9 | chr7:27202058-27205149:- | -0.41 | -4.59 | 5.8E-6 | Hypospadias |
| THCA | cis | rs41997 | 1 | rs6948433 | chr7:118030666 | ANKRD7 | chr7:117864712-117882782:+ | -0.27 | -4.33 | 1.78E-5 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs2243480 | 1 | rs6949812 | chr7:65387101 | CCT6P1 | chr7:65216092-65228661:+ | 0.39 | 6.18 | 1.36E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6949812 | chr7:65387101 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.99 | 7.58E-5 | Diabetic kidney disease |